[Discussion] can we stop arguing about dose stretching until somebody posts a number
Question in the title, detail here: can we stop arguing about dose stretching until somebody posts a number. Drifted up 6kg over a winter and panicked. It came back off without any change, which is apparently just what weight does. Two years at maintenance. The logistics are the only remaining work — ordering,…
Interval stretching changes the exposure profile: with a week-long half-life, moving to ten or twelve days lowers trough concentration more than it lowers average exposure. That is why appetite return is often the first thing noticed.
Interval stretching changes the exposure profile: with a week-long half-life, moving to ten or twelve days lowers trough concentration more than it lo
Agreed — and appetite is the leading indicator. The scale is the lagging one.
maintenance is where the logistics finally get boring, which is the point
Has appetite changed, or only the scale?
Correction: that trial measured regain after withdrawal, not failure of the drug during treatment. Very different claim.
the lowest effective dose is a real target and nobody talks about it
the trials that looked at withdrawal are unambiguous about what follows
Agreed — and appetite is the leading indicator.
This reframing is the most useful thing on the board for anyone approaching this phase.
appetite returns before the scale acknowledges anything