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c/maintenancephase·submitted 2 years ago by u/copay_card_cc

how much of what we believe about dose stretching actually comes from regain threads

Regainbranch of 8 comments

Asking properly rather than in a comment on somebody else’s thread: how much of what we believe about dose stretching actually comes from regain threads. On stopping, since it is the question underneath most posts here. Withdrawal studies in this class show substantial regain after discontinuation, consistently,…

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8 comments, started 2 years ago
u/rasmus_petrescu154 points·2 years ago

Appetite returning before the scale moves follows from the mechanism: the appetite effect is the proximal one and weight is the lagging integrated outcome.

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u/zaid_eriksen74 points·2 years ago·edited

Body weight varies by a couple of kilos over days in stable people through fluid, glycogen and gut content. A range is not a trend.

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u/dario_petrescu60 points·2 years ago

Push back: that is not a plateau, that is maintenance. You have arrived and you are describing it as a failure.

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u/oskar_malinowski-8 points·2 years ago

Chased the last three kilos with a dose increase and got a fortnight of muscle cramps and no change in the number.

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u/kenji_vasquez1 point·2 years ago

maintenance is where the logistics finally get boring, which is the point

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u/copay_card_ccOP1 point·2 years ago

Correction: that trial measured regain after withdrawal, not failure of the drug during treatment. Very different claim.

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u/copay_card_ccOP0 points·2 years ago

What is the plan if the drift continues for another month?

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u/incretin_ivypharmacology1 point·2 years ago

Yes — interval stretching and dose reduction are different levers and people use the words interchangeably.

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The part nobody posts about: what happens at goal weight. Finding a lowest effective dose, dose-interval stretching, regain risk data, muscle retention, the psychology of not having a number to chase, and staying on indefinitely versus tapering.

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