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c/hplc·submitted 1 months ago by u/egfr_watcher

[Lab] split one vial across VendorInvestigate and PeptideMeter — 98.6% and 98.4%

Labbranch of 7 comments

Short version of the title, which is already short: split one vial across VendorInvestigate and PeptideMeter — 98.6% and 98.4%. Longer version underneath. Figures up front so nobody has to dig: 98.6% and 98.4%. Reading a trace posted here, in the order I actually look at things. Axes first — if the wavelength and the…

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7 comments, started 1 months ago
u/hana_lehtinen361 points·1 months ago

LC-MS for identity, UV for relative quantity

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u/hedda_ekstrom118 points·1 months ago

you cannot report to two decimals off that baseline

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The analytical deep end: RP-HPLC methods, gradient design, integration decisions, LC-MS confirmation, amino-acid analysis, water content, and why two labs can report 98.1% and 96.4% on the same vial and both be right. Post the chromatogram, not the summary line.

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