receptor is the most under-discussed thing on this board
Posting this as a discussion rather than a claim: receptor is the most under-discussed thing on this board. Tolerance to the gastric effect develops with continued exposure while the appetite effect largely persists. That single fact explains most of the "it settles but it still works" pattern the side-effect board…
Speculation is welcome here if it is labelled. This one has been relabelled rather than removed.
Small fix — it slows gastric emptying, it does not halt it, and the distinction matters for the mechanism you are proposing.
Tried to build a mental model from mechanism alone and produced a confident prediction that the trial data flatly contradicted.
Correcting my own comment: I attributed that to the GIP arm and the paper attributes it to the GLP-1 arm.
That study was in a rodent model. Worth stating, since the thread has been reading it as human data.
mechanism explains a direction, not a magnitude
Does the effect persist with continued dosing or does tolerance develop?
receptor agonism is not the same as receptor activation in every tissue
half-life is why these are weekly and not daily
the peripheral and central stories are not in competition
That conflates receptor affinity with clinical potency. They are related and they are not the same thing.
Right — mechanism gives you a direction. It never gives you an effect size and people use it as though it does.
gastric emptying slows, it does not stop