[Meta] proposal — a flair for half-life posts
Putting this to the board: proposal — a flair for half-life posts. Why mechanism talk keeps misleading people, including me. A mechanism tells you a direction. It does not tell you a magnitude, a timescale, or whether the pathway is operative at the exposures involved. "Receptor X is expressed in tissue Y" is a fact;…
Glucose-dependent insulin secretion is why hypoglycaemia risk is low as monotherapy: the effect scales with glycaemia rather than acting unconditionally.
Long half-life in this class comes from structural modification that promotes albumin binding and resists enzymatic degradation. Weekly dosing is a consequence of the molecule, not a convenience decision.
Small fix — it slows gastric emptying, it does not halt it, and the distinction matters for the mechanism you are proposing.
dose response is not linear and nobody should assume it is
Spent an evening on the receptor distribution literature and the side-effect map suddenly stopped looking random.