the stability question that gets asked weekly, answered properly
The title is the argument: the stability question that gets asked weekly, answered properly. Here is the rest of it. You cannot infer potency from a temperature record. The record tells you what happened to the box; only a test tells you what happened to the material. Regional stock changes the question rather than…
Lyophilisation removes the water that drives most degradation pathways. That is why the dry cake is comparatively robust and the reconstituted solution is not.
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What was the packaging — rigid outer, gel packs, anything insulating?
Small fix — refrigerated, not frozen, once it is in solution.
Cosigning the regional stock point. Ordering from a warehouse in Poland took the whole question off my table.
regional stock removes most of this problem entirely
the door shelf is the worst place in the fridge
a warm gel pack tells you the pack failed, not that the material did
Yes — reconstitution date on the vial. It is the number you will want and cannot reconstruct.
Correction: that stability figure covers the lyophilised powder, not the reconstituted solution. Different claim entirely.
How many days in transit, and which month?
That is the ambient temperature at the destination, not the temperature inside the box. The logger measures the second one.
Gel packs are designed for a duty cycle. A liquid pack at the end of a longer-than-expected transit is a pack behaving as specified, not evidence of an excursion in the vial.
Correcting myself above: the transit was 3 days, not the figure I posted. Same conclusion, wrong number.
a logger costs less than a vial and answers the question permanently