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c/coldchain·submitted 21 days ago by u/ines_lindqvist

freezing reconstituted product: why the answer is no

Databranch of 6 comments

freezing reconstituted product: why the answer is no. Not a hot take, just something I have not seen said plainly here. Once in solution, the relevant risks are hydrolysis, aggregation and, for some sequences, oxidation. Refrigeration slows all three; freezing a solution introduces a separate risk at the ice…

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6 comments, started 20 days ago
u/marta_ilunga190 points·20 days ago

A stability statement is only meaningful with its conditions attached: temperature, duration, light exposure, and whether it covers powder or solution. Ask which.

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u/ines_lindqvistOP72 points·19 days ago

fridge, not freezer, once it is in solution

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u/emeka_delgado79 points·19 days ago

I would not freeze it in solution. That is a different failure mode and a worse one.

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u/rohan_steiner27 points·19 days ago·edited

I would not freeze it in solution.

This is the distinction that resolves most threads here — powder and solution are different problems.

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u/ilias_steiner7 points·19 days ago

ask which lines are held in regional stock before you order in July

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u/hplc_hobbyistruns their own column21 points·19 days ago·edited

Small fix — refrigerated, not frozen, once it is in solution.

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