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c/coa·submitted 4 months ago by u/anya_moreau

[PSA] purity is not what most of this community thinks it is

COAbranch of 8 comments

purity is not what most of this community thinks it is. Two minutes of reading now saves an argument later. My first certificate had a compound name, a percentage and a logo. I thought that was normal. It is not, and now I know what to ask for. How to ask for a batch record without it turning into a negotiation. One…

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8 comments, started 4 months ago
u/coa_janitorMOD57 points·4 months ago

Left up and flaired Explainer. This is the answer we keep linking, written properly.

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u/zeynep_zielinski20 points·4 months ago

Not quite. Two labs with different gradients can resolve a close-eluting impurity differently and both be reporting honestly.

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u/coa_janitormod · c/coa5 points·4 months ago

The PDF creation date being later than the analysis date is usually a re-issue or a re-export. It is worth one question and it is not evidence of anything on its own.

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u/bastian_moreau16 points·4 months ago

Pushing back a little: a missing field is usually presentation, not concealment. Ask for the full document before drawing conclusions.

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u/anya_moreauOP10 points·4 months ago

That is the catalogue certificate rather than the batch-specific one. Same layout, completely different status.

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u/sofia_danquah5 points·4 months ago

Yes. The structure of the document matters at least as much as the number printed on it.

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u/marisol_frisk6 points·4 months ago·edited

Correction: that is net peptide content, not purity. Different number, different meaning, and the document says so if you read the row label.

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u/kavya_verhoeven14 points·4 months ago

Started keeping a folder of every certificate I have been sent. The ones that itemise impurities are a small group and they are mostly the same suppliers.

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How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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