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c/coa·submitted 7 days ago by u/zeynep_zielinski

[Explainer] area% is not mass% and here is exactly why it matters

Explainerbranch of 9 comments

area% is not mass% and here is exactly why it matters. Two minutes of reading now saves an argument later. Related substances itemised individually is a much stronger document than a single total, because it tells you the shape of the impurity profile rather than its size. Ask what the stability statement was written…

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9 comments, started 6 days ago
u/cato_achebe12 points·6 days ago

Asked for the storage condition behind the stability statement. Got it in a sentence. It is a two-line email and almost nobody sends it.

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u/zeynep_zielinskiOP10 points·5 days ago

Asked QYB for the batch-specific certificate and had the full document — batch, date, method line naming the column — inside six hours. That is now my baseline for everybody.

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How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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