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c/cagrilintide·submitted 3 days ago by u/liv_dumitru

amylin is not a GLP-1 and the co-agonism story is more interesting than the weight number

Questionbranch of 6 comments

The title is the argument: amylin is not a GLP-1 and the co-agonism story is more interesting than the weight number. Here is the rest of it. Kept a log purely because so few people are logging this one. It is one person and it is not data. The tolerability tables were more informative than the headline numbers,…

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6 comments, started 3 days ago
u/amara_kuipers23 points·3 days ago

Nothing containing this compound is approved as a standalone product, and research-use-only material is not approved for human use.

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u/sten_rautio11 points·3 days ago

Small fix — amylin analogue, not a GLP-1 analogue. The whole mechanism argument changes on that word.

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u/liv_dumitruOP5 points·2 days ago·edited

That result is preclinical. Worth flagging, since the thread has been reading it as human data.

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u/ms_fragmenter2 points·2 days ago

Correction: that is the combination programme, not the monotherapy readout. Different arms, different numbers.

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u/rina_sobczak1 point·1 days ago

the co-agonism argument is about complementary mechanisms

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u/lucia_bruun14 points·2 days ago

Same view — long-acting is the engineering achievement here, and it is why the molecule exists at all.

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