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c/cagrilintide·submitted 3 months ago by u/ms_fragmenter

8 months in and amylin is still the thing I get wrong

Cautionbranch of 6 comments

Check-in as promised in the title: 8 months in and amylin is still the thing I get wrong. 8 months. Those are measured, not estimated, and not rounded up in my favour. Kept a log purely because so few people are logging this one. It is one person and it is not data. Asked a question here that turned out to be based…

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6 comments, started 3 months ago
u/hedda_aguirre14 points·3 months ago

Not convinced. Amylin signalling is not a GLP-1 pathway and the mechanism you are proposing conflates them.

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u/lane_map_larrylogistics7 points·3 months ago

Careful — that is a dosing intuition carried over from another board and there is no basis for it here.

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u/amara_kuipers4 points·3 months ago

Careful — that is a dosing intuition carried over from another board and there is no basis for it here.

This is the distinction that keeps this board honest — different axis, not a stronger version of the same one.

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u/micro_bump_mick2 points·3 months ago

REDEFINE is the combination programme

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u/teodor_lokken1 point·3 months ago

Independent purity data on this compound is sparse compared with the older molecules, simply because far fewer members have paid for testing. Sparse data means wide uncertainty, not a verdict.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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