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c/cagrilintide·submitted 18 days ago by u/egfr_watcher

[Trial Data] nausea rates in the combination arm vs sema alone

Trial Databranch of 6 comments

nausea rates in the combination arm vs sema alone — a position I have arrived at slowly and would like tested. Went looking for independent results on this and found a handful across the whole site. That is the honest state of the evidence. Asked a question here that turned out to be based on a mechanism confusion.…

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6 comments, started 18 days ago
u/forest_plot_fionastats11 points·18 days ago

Bought small deliberately because the evidence base is thin. That felt like the only defensible approach.

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u/egfr_watcherOP6 points·17 days ago

That result is preclinical. Worth flagging, since the thread has been reading it as human data.

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u/sten_rautio2 points·17 days ago

long-acting amylin is the whole point of the molecule

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u/ines_ekstrom0 points·17 days ago

That result is preclinical.

Disagreeing with this line: that figure is from a combination arm and is being quoted as monotherapy.

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u/pancreatitis_scare1 point·17 days ago

REDEFINE is the combination programme

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u/milos_vestergaard1 point·17 days ago

amylin analogue, different receptor family, different story

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