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Single comment threadYou are looking at one branch of the co-agonism thing finally clicked for me and I want to write it down — 33 comments in the full submission. View in context.
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c/cagrilintide·submitted 11 months ago by u/freya_baptista

the co-agonism thing finally clicked for me and I want to write it down

Discussionbranch of 9 comments

Thinking out loud about this: the co-agonism thing finally clicked for me and I want to write it down. Nothing containing this compound is approved as a standalone product, and research-use-only material is not approved for human use. Dosing intuitions from the GLP-1 boards do not transfer. Different receptor family,…

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9 comments, started 11 months ago
u/viktor_erdogan33 points·11 months ago

Do you have the publication or a summary of it?

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u/milan_mensah23 points·11 months ago

Complementary mechanisms are the rationale for pairing: satiety signalling alongside incretin signalling, rather than more agonism at the same receptor.

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u/bpc_scepticresearch peptides15 points·11 months ago

Careful — that is a dosing intuition carried over from another board and there is no basis for it here.

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u/liv_dumitru8 points·11 months ago·edited

Correction: that is the combination programme, not the monotherapy readout. Different arms, different numbers.

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u/nl_verzekering39 points·11 months ago

read the combination arms separately from the monotherapy arms

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u/hedda_aguirre21 points·11 months ago

This. Complementary mechanisms rather than more of the same is the actual argument for the pairing.

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u/zeynep_weiss7 points·11 months ago

amylin and GLP-1 are not redundant pathways

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u/throwaway_44b12 points·11 months ago

REDEFINE is the combination programme

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u/niels_norgaard32 points·11 months ago

Asked a question here that turned out to be based on a mechanism confusion. Three people untangled it patiently.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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