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c/cagrilintide·submitted 6 months ago by u/teodor_lokken

how much of what we believe about cagrilintide actually comes from CagriSema threads

Labbranch of 8 comments

how much of what we believe about cagrilintide actually comes from CagriSema threads. If this has been answered properly somewhere, link me and I will delete. The tolerability tables were more informative than the headline numbers, which is usually the case and never how it gets summarised. Read the combination paper…

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8 comments, started 6 months ago
u/pavel_halvorsen12 points·6 months ago

Yes. Anyone reading this board should hold their conclusions loosely until phase 3 reports.

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u/incretin_ivyMOD9 points·6 months ago

Left up. Thin evidence base, honestly labelled, which is the standard here.

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u/milan_mensah7 points·6 months ago

How many separate lots has anyone here tested?

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u/ferritin_low5 points·6 months ago

Small fix — amylin analogue, not a GLP-1 analogue. The whole mechanism argument changes on that word.

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u/zeynep_ndiaye7 points·6 months ago

Complementary mechanisms are the rationale for pairing: satiety signalling alongside incretin signalling, rather than more agonism at the same receptor.

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u/teodor_lokkenOP3 points·6 months ago

Are you comparing against a GLP-1 monotherapy result? They are not comparable.

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u/lane_map_larrylogistics2 points·6 months ago

Which trial and which readout?

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u/teodor_lokkenOP1 point·6 months ago

Is there any independent purity data on this compound that you have seen?

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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