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c/cagrilintide·submitted 1 year ago by u/yara_mensah

[Results] 2 weeks on 7.5mg, full numbers, ask me anything boring

Labbranch of 6 comments

2 weeks on 7.5mg, full numbers, ask me anything boring. Full detail below, and I have tried to keep the editorialising out of it. Pulling the figures out of the title: 2 weeks and 7.5mg. All of it is written down as it happened rather than reconstructed. The engineering problem was duration: native amylin is…

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6 comments, started 1 year ago
u/lucia_bruun15 points·1 year ago

Do you have the publication or a summary of it?

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u/yara_mensahOP8 points·1 year ago

Small fix — amylin analogue, not a GLP-1 analogue. The whole mechanism argument changes on that word.

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u/hydration_hank3 points·1 year ago

Correcting myself upthread: I gave the 48-week figure and the paper reports 94 weeks.

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u/signe_grimaldi2 points·1 year ago

do not assume the dosing intuitions from the GLP-1 boards transfer

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u/milan_mensah0 points·1 year ago

Correction: that is the combination programme, not the monotherapy readout. Different arms, different numbers.

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u/rt_shift_reggie6 points·1 year ago

That result is preclinical. Worth flagging, since the thread has been reading it as human data.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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