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c/bpc157·submitted 1 year ago by u/marit_sandvik

sequence — 10 things I got wrong before I got it right

Cautionbranch of 10 comments

sequence — 10 things I got wrong before I got it right. Not a hot take, just something I have not seen said plainly here. Every claim I could trace in this board went back to about four papers. That was a sobering afternoon. Asked SWB for the theoretical mass alongside the certificate and they sent it without asking…

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10 comments, started 1 year ago
u/marta_ilunga93 points·1 year ago

It is a fifteen-residue peptide with a published sequence, which makes synthesis straightforward and makes identity verification the meaningful test rather than an optional extra.

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u/hplc_hobbyistruns their own column52 points·1 year ago

identity, quantity, stability — three separate questions

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u/marit_sandvikOP-22 points·1 year ago

What method produced that purity number?

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u/rui_only_roMOD53 points·1 year ago·edited

Added a jurisdiction tag to the regulatory question. The answer differs and has changed.

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u/marit_sandvikOP30 points·1 year ago

Correction: that study was in rodents. Worth stating explicitly since the thread has been reading it as clinical.

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u/marit_sandvikOP19 points·1 year ago

Was there identity confirmation, or only a purity figure?

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u/viktor_laurent77 points·1 year ago

read the actual papers, they are more modest than the summaries

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u/sequence_checkerresearch peptides26 points·1 year ago

pentadecapeptide, fifteen residues, and the sequence is public

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u/honest_syringe2418 points·1 year ago

What jurisdiction are you asking about? The answer has changed in several.

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u/ms_fragmenter26 points·1 year ago

Right, and regulatory status has genuinely moved in several jurisdictions. Answers from three years ago may be wrong now.

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About c/bpc157

BPC-157 as it actually is: a pentadecapeptide with a genuinely interesting rodent tendon-and-gut literature, near-zero controlled human data, a naming and sequence mess in the supply chain, and a regulatory status that changed sharply in several countries.

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