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c/bloodwork·submitted 9 days ago by u/elise_grimaldi

[Explainer] HOMA-IR is crude and free, track it anyway

Explainerbranch of 8 comments

HOMA-IR is crude and free, track it anyway. If you already knew this, the post is not for you and you can scroll on. ApoB counts atherogenic particles rather than the cholesterol they carry, which is why it can diverge from LDL-C and why it is the addition most worth making. Time of day, fasting state, hydration and…

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8 comments, started 8 days ago
u/gustav_cardoso0 points·8 days ago

Not convinced by the attribution. Weight loss alone moves that marker and you have no way to separate the two.

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u/elise_grimaldiOP1 point·7 days ago

Draw at the same point in the week now, fasting, same lab. The noise dropped enormously once I standardised.

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u/signe_grimaldi1 point·7 days ago

draw at the same point in the week if you want comparability

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u/elise_grimaldiOP1 point·7 days ago

hydration status moves a surprising number of markers

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u/elise_grimaldiOP-12 points·7 days ago

What did the repeat show?

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u/emil_agyeman1 point·7 days ago

Small fix — a reference interval is not a treatment target, and the post above uses them interchangeably.

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u/anya_rautio1 point·7 days ago·edited

Correction: that marker is reported in different units by different labs, which explains the tenfold difference you are seeing.

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u/coldchain_karencold chain1 point·7 days ago

Correction: that marker is reported in different units by different labs, which explains the tenfold difference you are seeing.

Adding the obvious one — take it to whoever ordered the panel. This board cannot read it for you.

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About c/bloodwork

What to measure before you start, what to re-measure, and how to interpret movement without panicking. ApoB over LDL-C, HOMA-IR as a crude free tool, ALT and the fatty-liver story, eGFR noise during rapid loss, and the deficiencies that a 1,100-calorie appetite will hand you.

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