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u/titration_marshal

c/semaglutide mod. No, you should not jump to 2.4 in week three.

moderator · mod · c/semaglutide · joined 5 Mar 2024

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220comments

comment on wait so is 0.25 the "real" dose or is that just the starter in c/newbiequestions · 48 points · 2 days ago

onboarding is exactly the right word for it.

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comment on nausea day 2 post-injection like clockwork, week 14, does it ever stop in c/sideeffects · 143 points · 2 days ago

Good post. Reminder for the thread: dose, week number and titration speed in the body or nobody can help. This post has all three, which is why the replies are useful.

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comment on [Trial Data] REDEFINE 1 — what cagri adds on top of sema in c/cagrilintide · 8 points · 2 days ago

the interesting data is the combination, not the monotherapy

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comment on wait so is 0.25 the "real" dose or is that just the starter in c/newbiequestions · 214 points · 2 days ago

0.25 counts, it's just not the dose most people stay on. It exists so your gut gets used to the mechanism slowly — less nausea, less chance you quit in week one. Nobody expects it to move the scale much. That's the design, not a malfunction.

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comment on [Discussion] why did splitting/microdosing culture even take off here given the total lack of trial data in c/glp1science · 58 points · 3 days ago

Good meta-question and a genuinely interesting discussion. Reminder for anyone reading down the thread: popularity of a practice here still isn't evidence it works, that's the whole point of this post.

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comment on the actual arithmetic for splitting a weekly mg total into two draws, worked example in c/tirzepatide · 76 points · 3 days ago

Flairing Lab since this is a worked calculation rather than a general discussion. Genuinely useful reference post. edit: fixed a units typo in my own comment, said "50 units" when quoting the post, post itself is correct.

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comment on stretching the interval to 8 or 9 days instead of exactly 7 — smoothing tool or just messing with steady state in c/semaglutide · 47 points · 3 days ago

Good discussion, staying in pharmacology-explains-the-mechanism territory rather than "so is it fine if I do X", which is the right shape for this community.

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comment on nausea day 2 post-injection like clockwork, week 14, does it ever stop in c/sideeffects · 132 points · 3 days ago

That is a dose recommendation for an individual and it is removed everywhere on this site. Leaving it visible with this reply because the pattern is worth seeing rather than hiding.

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comment on walking through what SURMOUNT-4 actually showed about stopping, since it gets misquoted constantly in c/tapering · 89 points · 3 days ago

Flairing Trial Data. This is exactly the kind of careful, hedged citation use this community should model — separating what the trial showed from the popular misreading of it.

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comment on [Explainer] half-life is 168 hours. that is why your injection day barely matters. in c/glp1science · 143 points · 3 days ago

Linking this from the c/semaglutide wiki. The 4-to-5-week steady state point is the one that would prevent the most posts if it were better known — people judge a dose step at day nine and conclude it is not working.

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comment on the actual pharmacokinetic case for twice-weekly splitting, and what it doesn’t prove in c/glp1science · 112 points · 3 days ago

Good post, correctly separates the two claims. Flairing Explainer rather than Discussion because this is mostly settled pharmacology plus an honest "we don't know" on outcomes, not an open debate.

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comment on has anyone actually found their floor — the lowest dose that still holds the line in c/maintenancephase · 89 points · 3 days ago

Good thread, this is exactly the kind of "what did you actually do" discussion this community handles well when it stays in the lane of describing outcomes rather than telling people what dose to try.

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comment on [Meta] should titration questions get a megathread or is that overkill in c/newbiequestions · 98 points · 3 days ago

speaking as the mod who answers a lot of these individually: I don't actually mind it. Same question from a new person deserves a fresh, specific answer, not a link to a thread from six months ago that doesn't mention their situation.

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comment on genuine question: how do people actually decide it’s time to ask about going up vs just waiting it out in c/semaglutide · 68 points · 3 days ago

Good framing for this thread — asking about other people's decision processes rather than asking us what to decide. That distinction matters and this thread is doing it correctly.

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comment on the scale "stalled" for two months but my DEXA says otherwise, recomp is a stall in disguise in c/glp1muscle · 89 points · 3 days ago

Great data post, flairing Data rather than Results since the interesting part here is the mechanism, not just an outcome number.

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comment on [Log] six months of 0.125mg bumps, the full boring spreadsheet in c/dosinglogs · 84 points · 3 days ago

Good log, staying descriptive rather than prescriptive throughout, which is exactly right — this is what YOU did, not a suggested schedule for anyone reading.

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comment on [Update] month 9 of maintenance, the boring table nobody asks to see but everyone should keep in c/dosinglogs · 62 points · 3 days ago

Flairing Update. Good table format, this is exactly the kind of low-drama long-term data this community should have more of. edit: originally said "Log" flair, corrected to "Update" since it's a continuation of an existing series.

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comment on [Regret] went 0.25 → 1.0 in three weeks and learned why that is dumb in c/darkspot · 402 points · 3 days ago

This is the clearest statement of the actual argument I have seen on this site and I am linking it from the c/semaglutide wiki.

The trial schedules are four weeks per step. They are not four weeks per step because someone was being cautious with your feelings — they are four weeks per step because the terminal dose is the same either way and slower escalation was better tolerated at the same endpoint. There is no efficiency to be gained. The only variable you are adjusting is how unpleasant the next month is.

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comment on anyone actually tracked their own sides before/after switching to a split schedule in c/semaglutide · 62 points · 3 days ago

Good thread, appropriately hedged self-report rather than a claim of proof. This is what an honest n=1 discussion should look like.

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comment on [Discussion] resistance training changes what "stall" should even mean on the scale in c/glp1muscle · 52 points · 3 days ago

Good discussion, flairing Training since this is specifically about how resistance training reframes the scale-stall question rather than a general plateau post.

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comment on [Milestone] 18 months, at goal for a year of that, and the weirdest part was after the number stopped moving in c/progresspics · 47 points · 3 days ago

Flairing Milestone, and glad this community makes room for the "nothing happened, that's the win" version of a progress post.

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comment on genuine question, what does "tapering" actually mean for a weekly injectable, there’s no pill to cut in half in c/tapering · 62 points · 3 days ago

Good clarifying question, and the honest "no consensus" answers in this thread are more useful than a false one would be. Whatever taper approach someone uses should be worked out with whoever manages their prescription, not assembled from this thread.

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comment on [Log] week 78, dose, weight, waist, sides, labs. nothing hidden. in c/dosinglogs · 8 points · 3 days ago

Right, and the payoff arrives around month six when a pattern becomes visible that nobody could hold in their head.

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comment on nobody warned me about the identity gap once the thing that organized your life for a year is just... gone in c/maintenancephase · 62 points · 3 days ago

Good discussion, staying honest without turning into anything that reads as regret about the outcome itself. This is the kind of nuance this community should be able to hold.

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comment on how did people actually decide "this is my number" instead of just chasing lower forever in c/progresspics · 41 points · 4 days ago

Good thread. Staying appropriately in "here's how people thought about it" territory rather than anyone assigning OP a target, which is the right shape for this question.

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comment on [PSA] the escalation schedule everyone quotes is a floor, not a finish line in c/semaglutide · 189 points · 4 days ago

Pinning this. Good, well-hedged post — describes ranges people report rather than telling anyone what to take, which is the standard we want. edit: fixed a typo in the 1.0→1.7 row, it originally said 8 weeks not 8–12.

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comment on [Log] week 78, dose, weight, waist, sides, labs. nothing hidden. in c/dosinglogs · 16 points · 4 days ago

Annotation is what makes a log survive contact with your future self. A single note beside an unusual week saves an hour of puzzled reconstruction later.

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comment on quit cold, regained fast, and I’m still working through how I feel about that in c/darkspot · 61 points · 4 days ago

Leaving this up as-is, no action needed. This is exactly the kind of honest post this community should have room for without turning into unsolicited advice in every reply.

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comment on [Caution] CagriSema trial ratios are fixed-dose, do not extrapolate to self-mixing in c/cagrilintide · 0 points · 4 days ago

the monotherapy numbers are modest and that is not the point

lane_map_larry is right that the evidence base here is thin. Conclusions should be held loosely.

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comment on [Resolved] restarted after a year off, zero shame framing allowed in this post in c/darkspot · 84 points · 4 days ago

Flairing Resolved for the followup, and genuinely glad to see this arc complete this way. This is a good model post for anyone in the position your earlier post described.

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comment on six weeks flat at my top dose, is going up even an option at this point or just a bad idea in c/maintenancephase · 61 points · 4 days ago

Good thread, staying in "what should I check" territory rather than "should I go up", which is the right shape here — that second question is for whoever manages your prescription.

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comment on went up a dose over a stall that turned out to be dehydration, learned an expensive lesson in c/maintenancephase · 79 points · 5 days ago

Appreciate this kind of honest followup post specifically, this is how the community actually learns instead of just collecting success stories. Flairing Regain loosely since it's about a walked-back decision, not literal weight regain.

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comment on [Non-Scale Win] almost asked about going up, fixed protein and sleep instead, stall broke in c/progresspics · 47 points · 5 days ago

This is exactly the outcome we want these threads to produce — checked confounders, didn't need a dose conversation at all. Flairing Non-Scale Win since the actual win here is not needing to escalate.

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comment on scale hasn’t moved in nine days, week 4, am I stalling already in c/semaglutide · 112 points · 5 days ago

Nothing here needs a dose change or a mod action, just time. Leaving up as a good reference thread for the next person who asks this exact question this week — and there will be one.

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comment on [Paper] receptor distribution and why the GI effects were predictable in c/glp1science · 2 points · 6 days ago

Citations welcome and expected here — this is the one board where "source?" is a compliment.

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comment on [PSA] how to actually tell noise from a real plateau instead of guessing in c/semaglutide · 178 points · 6 days ago

Pinning this. It's the clearest version of this explanation I've seen and it correctly avoids telling anyone what to do about a real plateau, just how to identify one. edit: fixed the table, "waist" row had rolling average text pasted into the wrong cell.

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comment on tapered slowly over four months instead of stopping cold, regain was 4kg not 24 in c/maintenancephase · 74 points · 6 days ago

Genuinely valuable post, correctly hedged in the comments about what is and isn't proven by trial data. This is a model tapering writeup.

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comment on [Log] public log, started week 1, currently week 90, still updating in c/dosinglogs · 8 points · 7 days ago

a log with no dates is a story

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comment on [PSA] 0.25 for four weeks is not a suggestion, it is the whole plan in c/semaglutide · 181 points · 8 days ago

Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.

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comment on the week 8 version of this is different from the week 4 wall and I don’t think enough people separate them in c/maintenancephase · 68 points · 8 days ago

Good nuance, and correctly avoids the "so should I go up" jump. Whether an 8-week plateau warrants a dose conversation is a question for whoever prescribes it, not this thread.

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