u/throwaway_9182

Is the goal weight still the one you picked at the start?

Agreed — cheap to make is a double-edged fact and it explains a lot about this corner of the market.

Appetite returning before the scale moves follows from the mechanism: the appetite effect is the proximal one and weight is the lagging integrated out

This reframing is the most useful thing on the board for anyone approaching this phase.

Same. Monthly is plenty at this stage and daily weighing made me miserable for no information gain.

short peptides are cheap, which cuts both ways

This is the point that should be at the top of every thread here. Identity first.

stretching the interval is not the same as reducing the dose

Went and read the primary rodent papers after arguing about a summary for a week. They are much narrower than the threads suggest.

This is the point that should be at the top of every thread here.

Agreed — and the preclinical to clinical gap is where nearly all the overclaiming happens.

Yes — the rodent literature is real and it is rodent literature. The gap to a human claim is enormous and it gets crossed in one sentence here.