145
[Question] glucagon — what am I missing here
The title is the whole question — glucagon — what am I missing here — but here is why I am asking. It is a dual agonist at the GLP-1 and glucagon receptors. The…
survodutide
Every GLP Research Hub submission tagged to survodutide, ranked by score. Discussed in 1 community.
Communities covering this
129
unpopular opinion: most of what gets said here about MASH is guesswork
unpopular opinion: most of what gets said here about MASH is guesswork. It is the sort of thing everyone half-believes and nobody writes down. Asked here what the…
93
the biopsy question that gets asked weekly, answered properly
Something I keep coming back to: the biopsy question that gets asked weekly, answered properly. Sent a vial to Janoshik because there was nothing on file. 99.4% against…
92
[Vendor] BCH vs KP on the same compound, same month — both cleared 98.5%
Result first, context after: BCH vs KP on the same compound, same month — both cleared 98.5% . Everything below is how it was ordered, stored and sent. Figures up front…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standards77
[Discussion] small community, high signal, let us keep it that way
small community, high signal, let us keep it that way. Change my mind, genuinely — I have no stake in being right about this. Nothing containing this compound is…
77
[Results] 28 weeks, 11kg, and MASH was the hard part
28 weeks, 11kg, and MASH was the hard part. Same spreadsheet I have been keeping since the start, nothing retrofitted. Since the title puts numbers in the shop window:…
73
[Question] does the glucagon arm explain the heart rate signal
Trying to get a straight answer on this: does the glucagon arm explain the heart rate signal. The escalation schedules in the published protocols are slow and…
0
glucagon co-agonism has its own safety story, stop generalising from tirz
Something I keep coming back to: glucagon co-agonism has its own safety story, stop generalising from tirz. Bought small because the evidence base is early. That is the…
0
anyone else notice survodutide kicking in around week 89
Update, and the title has the headline: anyone else notice survodutide kicking in around week 89. Read the phase 2 hepatic paper properly and the endpoint definitions…
0
[Discussion] the hepatic fat advice in here is 2 years out of date
the hepatic fat advice in here is 2 years out of date. Change my mind, genuinely — I have no stake in being right about this. The relevant figures are 2 years, and they…
0
[Discussion] survodutide is doing more work than we give it credit for
survodutide is doing more work than we give it credit for. I have gone back and forth on this for months. What this compound is actually being developed for, since the…
-61
week 36 check-in — 12kg down, nausea manageable, one thing confusing me
Reporting in. week 36 check-in — 12kg down, nausea manageable, one thing confusing me. The numbers the title promised, since a headline without them is worthless: week…