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c/survodutide·posted 8 months ago by u/old_account_2023

week 36 check-in — 12kg down, nausea manageable, one thing confusing me

Paper

Reporting in. week 36 check-in — 12kg down, nausea manageable, one thing confusing me.

The numbers the title promised, since a headline without them is worthless: week 36 and 12kg. Everything below is context for those.

Sent a vial to PeptideMeter because there was nothing on file. 98.6% against a claimed 98.5%. First entry for this compound in my own log.

Looked for independent results across this whole site and found almost none. Worth knowing before forming an opinion.

Not medical advice, obviously, and nothing here is approved for human use. One person with a spreadsheet.

172 up / 233 down42% upvoted12 commentsid v79ye06 Nov 2025

12 comments

12 in this archive, depth 3

best — the order this archive was captured in

u/jarno_adeyemi0 points·8 months ago

Independent purity results for this compound are very sparse across the whole site, which means any impression about consistency is built on almost nothing.

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[removed]1 point·8 months ago

[removed by moderator]

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u/camila_trevino11 points·8 months ago

Bought small because the evidence base is early. That is the only defensible position I could construct.

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u/nadia_bakker9 points·8 months ago

the titration in the trials was slow and deliberate

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u/mod_cold_roommod · c/coldchain7 points·8 months ago

This. Biopsy-confirmed and imaging-suggested are different evidentiary categories and get run together constantly.

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u/patient_labslip_log7 points·8 months ago·edited

Asked here what the difference was between the imaging and biopsy endpoints and got a genuinely excellent answer.

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u/liver_enzyme_lizMOD5 points·8 months ago

Left up. It reads the paper carefully and is explicit about the population.

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u/old_account_2023OP0 points·8 months ago

How fast was the escalation in that protocol?

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u/coa_janitormod · c/coa5 points·8 months ago·edited

Push back: the evidence here is phase 2, in a specific population, and it does not support a general ranking.

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u/clara_restrepo3 points·8 months ago

do not import intuitions from the obesity programmes

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u/milan_mensah2 points·8 months ago

Cosigning on the glucagon arm. It is the mechanistic thread that connects the hepatic and the metabolic effects.

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u/old_account_2023OP2 points·8 months ago

That figure is from the obesity programme, and this thread is about the hepatic one.

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About c/survodutide

Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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