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c/survodutide·posted 1 year ago by u/thermal_mass_tom

[Discussion] the hepatic fat advice in here is 2 years out of date

Discussion Receipts ×8

the hepatic fat advice in here is 2 years out of date. Change my mind, genuinely — I have no stake in being right about this.

The relevant figures are 2 years, and they come from the same log I have kept the whole time.

Imaging-derived liver fat fraction is a surrogate. It correlates with histology imperfectly, and a trial reporting one is not reporting the other.

Phase 2 in a biopsy-confirmed population is a demanding design: recruitment is slow, the population is specific, and the results do not generalise to people who have not been characterised that way.

If two or three other people have done the same thing we might actually learn something. Alone it is an anecdote.

0 up / 0 down50% upvoted6 commentsid 1v995y15 Aug 2024

6 comments

6 in this archive, depth 5

best — the order this archive was captured in

u/farid_kuipers0 points·1 year ago

The escalation schedules in the published protocols are slow and deliberate, and the tolerability tables show why. That is a description of the trials rather than a suggestion for anybody.

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u/cato_girard1 point·1 year ago

The escalation schedules in the published protocols are slow and deliberate, and the tolerability tables show why.

Adding the standing caveat — unapproved compound, research material is not for human use.

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u/ismael_nwosu1 point·1 year ago

That figure is from the obesity programme, and this thread is about the hepatic one.

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u/rafael_sjoberg1 point·1 year ago

the titration in the trials was slow and deliberate

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u/thermal_mass_tomOP1 point·1 year ago·edited

the titration in the trials was slow and deliberate

Disagreeing with this bit: that number comes from a different programme with a different population.

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u/thermal_mass_tomOP-20 points·1 year ago·edited

Are you reading the publication or a summary?

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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