receptor

how much of what we believe about mechanism actually comes from appetite threads — that is what I am asking, and I have already read the wiki twice. GIP receptor…

glucagon receptor agonism raising energy expenditure — how solid is that. Making the case below, and I expect to lose some of it in the comments. Asked a question here…

proposal — a flair for receptor posts, and it will stay as it is unless somebody makes the case to change it. The mental model, in four steps, that makes the rest of…

Posting this as a discussion rather than a claim: mechanism — 21 things I got wrong before I got it right. Tolerance to the gastric effect develops with continued…

incretin: what the trials say vs what this community says. Making the case below, and I expect to lose some of it in the comments. Long half-life in this class comes…

appetite is the most under-discussed thing on this board. Change my mind, genuinely — I have no stake in being right about this. GIP receptor biology is genuinely…

we are measuring half-life at the wrong time and calling it noise, and I am aware this is a minority view on this board. Read the primary paper after arguing about the…

Slightly embarrassed to be asking this, but: can we stop arguing about receptor until somebody posts a number. Long half-life in this class comes from structural…

Slightly embarrassed to be asking this, but: can we stop arguing about half-life until somebody posts a number. Asked a question here that I thought was stupid and got…

Asking properly rather than in a comment on somebody else’s thread: why does GIP agonism seem to reduce nausea rather than add to it. Why mechanism talk keeps…

Posting this as a discussion rather than a claim: unpopular opinion: most of what gets said here about pharmacology is guesswork. Why mechanism talk keeps misleading…

biased agonism: real, interesting, almost certainly irrelevant to your dose. I have gone back and forth on this for months. Was completely wrong about the gastric…

gastric emptying — 12 things I got wrong before I got it right. It is the sort of thing everyone half-believes and nobody writes down. Started reading limitations…

unpopular opinion: most of what gets said here about incretin is guesswork. Making the case below, and I expect to lose some of it in the comments. Asked a question…

The title is the whole question — does pharmacology actually matter or is it forum lore at this point — but here is why I am asking. The incretin effect is the…

pharmacology is the most under-discussed thing on this board. Change my mind, genuinely — I have no stake in being right about this. GIP receptor biology is genuinely…

we use "appetite suppression" to describe three different mechanisms. It is the sort of thing everyone half-believes and nobody writes down. Started reading limitations…

Every week somebody asks whether Tuesday is better than Sunday, and every week the answer is buried under anecdote. Semaglutide's terminal half-life is roughly 168…

Question in the title, detail here: can we stop arguing about appetite until somebody posts a number. The incretin effect is the observation that oral glucose provokes…

the mechanism advice in here is 3 years out of date. It is the sort of thing everyone half-believes and nobody writes down. The relevant figures are 3 years, and they…

receptor distribution and why the GI effects were predictable. Change my mind, genuinely — I have no stake in being right about this. Tried to build a mental model from…

proposal — a flair for incretin posts. This affects how posts get sorted and removed, so it belongs in the open. Started reading limitations sections first. It has…

incretin is not what most of this community thinks it is, written plainly and without the jargon that usually swallows this topic. The mental model, in four steps, that…

"it heals your metabolism" is not a mechanism. It is the sort of thing everyone half-believes and nobody writes down. GLP-1 receptor agonism acts both peripherally —…