197
a pill with no food restrictions and no cold chain changes this entire site
Flairing this Speculation because that is what it is. Orforglipron is a small molecule, not a peptide. ATTAIN-1 and ACHIEVE-1 (both NEJM , 2025) reported the efficacy…
non-peptide
Every GLP Research Hub submission tagged to non-peptide, ranked by score. Discussed in 1 community.
Communities covering this
143
[Results] 55 weeks on 5mg, full numbers, ask me anything boring
Reporting in. 55 weeks on 5mg, full numbers, ask me anything boring. The relevant figures are 55 weeks and 5mg, and they come from the same log I have kept the whole…
137
why does nobody talk about non-peptide
Genuine question, and the title is the question: why does nobody talk about non-peptide. The no-timing-restriction thing is the part I would care about most in…
120
reading non-peptide threads from 2024 and half of it aged badly
reading non-peptide threads from 2024 and half of it aged badly. Making the case below, and I expect to lose some of it in the comments. The no-timing-restriction thing…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standards107
someone explain ATTAIN to me like I have not read a paper in years
Asking properly rather than in a comment on somebody else’s thread: someone explain ATTAIN to me like I have not read a paper in years. Went looking for independent…
32
switched from 10mg to 15mg and constipation got better, not worse
Something I keep coming back to: switched from 10mg to 15mg and constipation got better, not worse. Since the title puts numbers in the shop window: 10mg and 15mg.…
0
what changed for me between month 12 and month 18
what changed for me between month 12 and month 18. If this has been answered properly somewhere, link me and I will delete. Daily rather than weekly sounds trivial…
0
[Results] 46 weeks, 21kg, and orforglipron was the hard part
Six-word version is the title — 46 weeks, 21kg, and orforglipron was the hard part — and the rest is context. The numbers the title promised, since a headline without…
0
week 64 check-in — 25kg down, early fullness manageable, one thing confusing me
week 64 check-in — 25kg down, early fullness manageable, one thing confusing me. Same spreadsheet I have been keeping since the start, nothing retrofitted. To save the…
-23
unpopular opinion: most of what gets said here about orforglipron is guesswork
unpopular opinion: most of what gets said here about orforglipron is guesswork. Making the case below, and I expect to lose some of it in the comments. Oral semaglutide…
-24
[Results] 70 weeks on 2.4mg, full numbers, ask me anything boring
Update, and the title has the headline: 70 weeks on 2.4mg, full numbers, ask me anything boring. 70 weeks and 2.4mg. Those are measured, not estimated, and not rounded…
-79
help me understand oral GLP-1, I have read the wiki twice
Slightly embarrassed to be asking this, but: help me understand oral GLP-1, I have read the wiki twice. Holding off on any opinion until phase 3 reports. That is not a…
-82
how much of what we believe about ACHIEVE actually comes from ATTAIN threads
how much of what we believe about ACHIEVE actually comes from ATTAIN threads. I would rather ask a basic question now than get this wrong quietly for two months.…