SURPASS — 6 things I got wrong before I got it right
SURPASS — 6 things I got wrong before I got it right. It is the sort of thing everyone half-believes and nobody writes down. Spent an evening with the appendix tables and found the subgroup detail that the entire thread had been speculating about. Quoted a figure here confidently, got asked whether it was ITT, went…
That is a relative risk reduction. Quoting it without the absolute numbers overstates the case considerably.
registry entry, protocol, publication — three different documents
Correcting myself upthread: I gave the completer figure and labelled it intention-to-treat.
Small fix — that was the cardiovascular outcomes trial, so weight was a secondary endpoint and the population was different.
A confidence interval is the range of effects compatible with the data. Two trials with overlapping intervals have not disagreed, whatever their point estimates look like next to each other.
Push back: an open-label extension tells you about the people who stayed. That is a different question.
How long was the randomised phase before any extension?