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c/tirzepatide·posted 1 year ago by u/elin_varga

[Discussion] can we stop arguing about GIP until somebody posts a number

Discussion Well Actually ×9 Slow Clap ×2 Receipts ×1

Genuine question, and the title is the question: can we stop arguing about GIP until somebody posts a number.

Week 47 was the first time the scale moved after a five-week stall. I changed nothing in that window.

The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.

Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.

That is everything I have. The rest is opinion and I have tried to keep it out.

4,516 up / 491 down90% upvoted50 commentsid tozstz16 Nov 2024

50 comments

14 in this archive, depth 5

best — the order this archive was captured in

u/rania_marchand610 points·1 year ago

Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.

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u/piotr_nascimento518 points·1 year ago

Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.

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u/elin_vargaOP603 points·1 year ago

25kg over 64 weeks, never went past 10mg, and early fullness stayed mild the whole way. Posting because the loud threads are all 15mg.

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u/signe_villalobos240 points·1 year ago

Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.

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u/elin_varga349 points·1 year ago

Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.

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u/elin_vargaOP162 points·1 year ago

hold the dose that works, the ladder is not a leaderboard

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u/certified_referenceQC135 points·1 year ago

Correction to my own post above — I said 5mg and I have been on 5mg since the spring. Same argument, wrong number.

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u/sten_palacios58 points·1 year ago

2.5 is the starter dose and it is not meant to be the dose that works

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u/alcohol_aversion44 points·1 year ago

2.5 is the starter dose and it is not meant to be the dose that works

Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.

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u/emil_okwuosa257 points·1 year ago

Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.

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u/ignacio_vanhecke-14 points·1 year ago

Pen or vial? The step sizes available differ and it changes this answer.

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u/elin_vargaOP-20 points·1 year ago

Are you comparing yourself with the trial mean or with the people who post the most?

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u/slow_logbook_ftw1 point·1 year ago

stepping every four weeks is a ceiling on speed, not a schedule you must hit

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u/mikkel_kimani1 point·1 year ago

sulphur burps are the signature complaint and they are not dangerous

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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