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c/tirzepatide·submitted 1 year ago by u/slow_logbook_ftw

stalled for 18 weeks at 12.5mg and I refuse to panic this time

Labbranch of 6 comments

stalled for 18 weeks at 12.5mg and I refuse to panic this time — a position I have arrived at slowly and would like tested. To save the first four comments: 18 weeks and 12.5mg. Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule. The thing nobody warned me about…

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6 comments, started 1 year ago
u/piotr_nascimento161 points·1 year ago

The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.

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u/marit_sandvik67 points·1 year ago·edited

Correction to my own post above — I said 2.5mg and I have been on 15mg since the spring. Same argument, wrong number.

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u/slow_logbook_ftwOP44 points·1 year ago

14kg over 53 weeks, never went past 10mg, and reflux stayed mild the whole way. Posting because the loud threads are all 15mg.

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u/slow_logbook_ftwOP41 points·1 year ago·edited

What step are you on and how long have you been there?

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u/fatima_wojcik13 points·1 year ago

zepbound and mounjaro are the same compound with different labels

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u/zaid_balogun6 points·1 year ago

Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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