someone explain 15mg to me like I have not read a paper in years
someone explain 15mg to me like I have not read a paper in years — that is what I am asking, and I have already read the wiki twice.
Hard numbers: 15mg. Anything softer than that is flagged as an impression.
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
I will update this if the picture changes rather than quietly leaving it up.
best — the order this archive was captured in
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
This is the fifth "should I go up" post today and they are all welcome — but no member here can answer it for you.
What is the waist doing? That is usually the number still moving during a scale stall.
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
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Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
23kg over 58 weeks, never went past 10mg, and muscle cramps stayed mild the whole way. Posting because the loud threads are all 15mg.
the four-week step schedule is the label, not folklore
dual agonist, so the GIP arm is doing something the sema threads will not tell you about
dual agonist, so the GIP arm is doing something the sema threads will not tell you about
emil_wojcik is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.
Have you held a step for longer than the four-week minimum at any point?
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
the nausea profile is genuinely gentler than people expect coming from sema
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
Week 74 was the first time the scale moved after a five-week stall. I changed nothing in that window.
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
a lot of people plateau nicely at 10mg and never need 15
SURMOUNT-1 landed around 21% at 72 weeks on the top arm
What step are you on and how long have you been there?
Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.
Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.
Did you come to this from sema, and if so how long was the gap?
hold the dose that works, the ladder is not a leaderboard
Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.
Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.
Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.
Does early fullness follow the day after the shot, or is it spread across the week?
the trials titrated on a calendar, real people titrate on symptoms
Cosigning the four-week thing.
Saving this one. It is the clearest statement of the stall problem I have read here.
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