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c/tirzepatide·submitted 1 year ago by u/marta_dziedzic

[Question] how do you actually verify Zepbound

Questionbranch of 6 comments

how do you actually verify Zepbound. I am not trying to be the "source?" guy. I would just like a source. The step schedule question, answered properly, because it comes up weekly. The label sets a minimum interval of four weeks between increases. That is a floor on how fast you may go, and it exists because…

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6 comments, started 1 year ago
u/signe_villalobos14 points·1 year ago·edited

The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.

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u/marta_dziedzicOP9 points·1 year ago·edited

Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.

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u/copay_card_cc3 points·1 year ago

Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.

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u/santiago_villalobos1 point·1 year ago

Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.

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u/rania_diallo1 point·1 year ago

Correction to my own post above — I said 10mg and I have been on 12.5mg since the spring. Same argument, wrong number.

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u/nordic_pricing13 points·1 year ago

the trials titrated on a calendar, real people titrate on symptoms

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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