[PSA] SURPASS is not what most of this community thinks it is
SURPASS is not what most of this community thinks it is. Two minutes of reading now saves an argument later.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
24kg over 50 weeks, never went past 10mg, and nausea stayed mild the whole way. Posting because the loud threads are all 15mg.
Please do not ask me what dose you should be on. I genuinely do not know and neither does anyone else here.
best — the order this archive was captured in
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
Does fatigue follow the day after the shot, or is it spread across the week?
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dual agonist, so the GIP arm is doing something the sema threads will not tell you about
if 7.5 is working, 10 is not automatically better
switching from sema is not a dose conversion, there is no clean equivalence
Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.
This matches mine. Milder fatigue than I expected, and what there was settled inside a fortnight of each step.
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads.
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
the appetite effect is blunter than sema, in a good way, most weeks
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
- 1It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part…9 comments in this branch · started by u/hub_ops