unpopular opinion: most of what gets said here about 15mg is guesswork
unpopular opinion: most of what gets said here about 15mg is guesswork, and I am aware this is a minority view on this board.
15mg. Those are measured, not estimated, and not rounded up in my favour.
32kg over 66 weeks, never went past 10mg, and injection-site soreness stayed mild the whole way. Posting because the loud threads are all 15mg.
Week 91 was the first time the scale moved after a five-week stall. I changed nothing in that window.
That is everything I have. The rest is opinion and I have tried to keep it out.
best — the order this archive was captured in
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
2.5 is the starter dose and it is not meant to be the dose that works
Removed the conversion table. There is no published equivalence between the two molecules and posting one as fact is exactly the kind of thing that gets copied for years.
Removed the conversion table.
This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
the appetite effect is blunter than sema, in a good way, most weeks
Are you comparing yourself with the trial mean or with the people who post the most?
Which week did the appetite change actually land for you?
Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 33 is not a fair reading.
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
stepping every four weeks is a ceiling on speed, not a schedule you must hit
I would separate the two claims. That the GIP arm exists is uncontroversial; that it explains your reflux pattern is a guess.
week 2 is early to draw any conclusion at all
- 1SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change.…7 comments in this branch · started by u/ahmed_iyer
- 2Weekly dosing again, half-life in the same neighbourhood as sema, so a step…6 comments in this branch · started by u/samir_falk