[Results] 26 weeks, 9kg, and dual agonist was the hard part
26 weeks, 9kg, and dual agonist was the hard part. Full detail below, and I have tried to keep the editorialising out of it.
To save the first four comments: 26 weeks and 9kg.
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
If somebody has the same thing measured a different way, post it next to mine and we will see whether they agree.
best — the order this archive was captured in
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
Correction to my own post above — I said 12.5mg and I have been on 12.5mg since the spring. Same argument, wrong number.
hold the dose that works, the ladder is not a leaderboard
pens and vials are the same molecule, the price is the difference
the appetite effect is blunter than sema, in a good way, most weeks
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
sulphur burps are the signature complaint and they are not dangerous
the four-week step schedule is the label, not folklore
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
a lot of people plateau nicely at 10mg and never need 15
Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.
2.5 is the starter dose and it is not meant to be the dose that works
Switching from semaglutide, since three people asked in this thread alone.
There is no published dose equivalence between the two. The conversion tables that circulate are somebody’s arithmetic, not data. What people report here is that the first month after a switch is often flat, that the appetite effect feels differently shaped rather than simply stronger, and that starting at the bottom of the ladder again is the common approach.
None of that is a recommendation. It is what the threads say, and the threads are not a clinic.
Yes — 10mg being a genuine landing place for a lot of people is underrated. There is no medal for 15.
Not sure that follows. You went up a step and changed your training in the same fortnight.
- 1Yes. I stepped to 12.5 because the calendar said so, not because anything…9 comments in this branch · started by u/matias_salgado