[Lab] split one vial across Janoshik and Medutest — 99.2% and 96.2%
split one vial across Janoshik and Medutest — 99.2% and 96.2%. One vial, one service, one member paying, which is the only kind of result this board should treat as evidence.
99.2% and 96.2% — those are the numbers, and they are the ones I am willing to defend.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
Sceptical readings welcome. The confident ones are the ones I distrust.
best — the order this archive was captured in
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
Research-use-only material is not approved for human use.
amara_halonen is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.
Which week did the appetite change actually land for you?
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
switching from sema is not a dose conversion, there is no clean equivalence
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
Are you comparing yourself with the trial mean or with the people who post the most?
dual agonist, so the GIP arm is doing something the sema threads will not tell you about
Does constipation follow the day after the shot, or is it spread across the week?
Does constipation follow the day after the shot, or is it spread across the week?
Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.
Removed the conversion table. There is no published equivalence between the two molecules and posting one as fact is exactly the kind of thing that gets copied for years.
What step are you on and how long have you been there?
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.
pens and vials are the same molecule, the price is the difference
- 1Research-use-only material is not approved for human use. Anything in this…7 comments in this branch · started by u/amara_halonen