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c/tirzepatide·submitted 2 years ago by u/mikkel_ogunleye

[Lab] split one vial across Medutest and Janoshik — 98.3% and 98.7%

Labbranch of 14 comments

Numbers in the title, numbers in the post. split one vial across Medutest and Janoshik — 98.3% and 98.7%. Since the title puts numbers in the shop window: 98.3% and 98.7%. Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it. Came off sema and onto…

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14 comments, started 2 years ago
u/elin_varga472 points·2 years ago

What is the waist doing? That is usually the number still moving during a scale stall.

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u/forest_plot_fionastats257 points·2 years ago

The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.

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u/mikkel_kimani263 points·2 years ago

It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.

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u/emil_okwuosa163 points·2 years ago

The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.

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u/alcohol_aversion189 points·2 years ago

Which week did the appetite change actually land for you?

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[deleted]119 points·2 years ago

[deleted]

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u/mikkel_ogunleyeOP44 points·2 years ago

Did you come to this from sema, and if so how long was the gap?

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u/b12_baseline35 points·2 years ago

pens and vials are the same molecule, the price is the difference

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u/laila_wikstrom23 points·2 years ago

if 7.5 is working, 10 is not automatically better

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u/tidy_vialdrawer_pls47 points·2 years ago

SURMOUNT-1 landed around 21% at 72 weeks on the top arm

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u/mikkel_ogunleyeOP34 points·2 years ago

2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.

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u/priya_guerrero227 points·2 years ago

Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.

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u/aksel_kjaer50 points·2 years ago·edited

Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.

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u/crosspost_bot_no144 points·2 years ago

hold the dose that works, the ladder is not a leaderboard

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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