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c/tapering·posted 1 year ago by u/fabio_lehtinen

someone explain interval stretching to me like I have not read a paper in years

Discussion

Trying to get a straight answer on this: someone explain interval stretching to me like I have not read a paper in years.

A written baseline — dose, date, weight, waist, and how appetite feels — taken before any change is what makes the following months interpretable rather than a series of impressions.

Appetite is the proximal effect and weight is the lagging integrated outcome, which is why watching appetite gives you an earlier and more honest signal.

Interval stretching lowers the trough concentration while keeping the dose; dose reduction lowers the level while keeping the rhythm. They are different interventions with different subjective profiles.

If somebody has the same thing measured a different way, post it next to mine and we will see whether they agree.

164 up / 54 down75% upvoted15 commentsid fx4b7j19 Dec 2024

15 comments

15 in this archive, depth 3

best — the order this archive was captured in

u/zeynep_weiss21 points·1 year ago·edited

There is very little published guidance on stopping specifically, which is exactly why board consensus here should carry less weight than usual and a clinician conversation should carry more.

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u/fabio_lehtinenOP25 points·1 year ago

Went back on after eight months away. Nobody here made me feel bad about it, which mattered more than I expected.

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u/cormac_roos17 points·1 year ago

Wrote down where I was before changing anything. That single page made the following six months interpretable.

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u/neha_mwangi-37 points·1 year ago

a fortnight of nothing is not evidence that you are fine

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u/taper_off_tabithaMOD9 points·1 year ago

Pointing the clinical part of this at somebody qualified. The experience part can stay here.

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u/camila_marchand4 points·1 year ago

Pointing the clinical part of this at somebody qualified.

This is the sentence that reframes the whole board. Appetite first, scale later.

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u/farid_kuipers3 points·1 year ago

Stopped abruptly once and gradually once. The gradual one was easier to interpret because I could see what was changing.

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u/vikram_asante6 points·1 year ago

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a chronic condition.

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u/arne_restrepo1 point·1 year ago

Nothing on this board is a taper schedule, and no member can write one for another. What can be shared is what people watched and what they observed.

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u/arne_restrepo1 point·1 year ago

stopping abruptly and stopping gradually are different experiences

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u/border_paperwork4 points·1 year ago

What the evidence says about stopping, written plainly because the framing does real damage.

Withdrawal studies across this class consistently show substantial regain after discontinuation. Appetite typically returns first, well before weight changes. This is a finding about the pharmacology of a chronic condition, in the same way that blood pressure rises again when an antihypertensive is stopped.

People on this board quit in shame over an entirely predictable result, and then avoid coming back because they have interpreted it as a personal failure. It is not. Knowing that in advance is the single most useful thing this board can offer anybody planning to stop.

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u/maintenance_mode_maxmaintenance3 points·1 year ago

With a week-long half-life, exposure declines over several weeks after the last dose rather than stopping with it. The lag is why the first fortnight is uninformative.

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u/vikram_ferreira4 points·1 year ago

Stopped for cost reasons. Appetite came back at about week 18, well before the scale moved, exactly as this board said it would.

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u/border_paperwork5 points·1 year ago

stretching to ten days then twelve is the pattern people report

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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