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c/t2dglp1·submitted 1 year ago by u/long_post_larry

unpopular opinion: most of what gets said here about CGM is guesswork

CGMbranch of 10 comments

unpopular opinion: most of what gets said here about CGM is guesswork. I have gone back and forth on this for months. The three numbers, and what each one can and cannot tell you. A1c is an average over about three months, weighted to the recent weeks. It cannot show variability and it lags change. Continuous…

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10 comments, started 1 year ago
u/emil_okwuosa24 points·1 year ago

The diabetes and obesity programmes are separate, with different populations and different primary endpoints. Reading a result across from one to the other is not a comparison.

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u/long_post_larryOP14 points·1 year ago

a1c can be affected by things that have nothing to do with glucose

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[removed]10 points·1 year ago

[removed by moderator]

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u/joaquin_stanescu7 points·1 year ago

Right, and the diabetes programmes report glycaemic endpoints. Quoting an obesity trial result here is answering a different question.

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u/fasting_insulin_f17 points·1 year ago

My A1c moved and it turned out to have nothing to do with glucose at all.

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u/bastian_eriksen9 points·1 year ago

Same. The first day of a new sensor is unreliable and people rebuild their whole week around it.

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u/farid_jansen10 points·1 year ago·edited

My A1c moved and it turned out to have nothing to do with glucose at all.

This is the distinction that resolves most of the confusion here — average versus shape.

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u/camila_vasquez5 points·1 year ago·edited

This is the distinction that resolves most of the confusion here — average versus shape.

Disagreeing with this line: that endpoint is from the obesity programme and does not answer the question.

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u/niels_salinas3 points·1 year ago

Disagreeing with this line: that endpoint is from the obesity programme and does not answer the question.

Agreed, and the glucose-dependence point is the reason the risk profile reads the way it does.

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u/hamza_weiss14 points·1 year ago

nothing here replaces the person managing your diabetes

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Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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