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c/survodutide·submitted 10 months ago by u/thermal_mass_tom

my ALT moved and I cannot work out whether dual agonist is why

Discussionbranch of 8 comments

Something I keep coming back to: my ALT moved and I cannot work out whether dual agonist is why. Imaging-derived liver fat fraction is a surrogate. It correlates with histology imperfectly, and a trial reporting one is not reporting the other. Nothing containing this compound is approved anywhere. Research-use-only…

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8 comments, started 10 months ago
u/injection_site_iris248 points·10 months ago

Histological endpoints in this field are scored on biopsy: resolution of steatohepatitis without worsening of fibrosis, or improvement in fibrosis without worsening of steatohepatitis. Both are harder to achieve and to interpret than an imaging surrogate.

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[deleted]111 points·10 months ago

[deleted]

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u/refund_ledger26 points·10 months ago

not approved anywhere, and the boards forget that constantly

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u/valeria_karlsen128 points·10 months ago

That is an escalation schedule for an unapproved compound and this board does not host those.

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u/vitamin_d_void45 points·10 months ago

glucagon agonism and energy expenditure is the mechanistic thread

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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