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Single comment threadYou are looking at one branch of three years of glucagon threads, summarised so you do not have to read them — 24 comments in the full submission. View in context.
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c/survodutide·submitted 1 months ago by u/marisol_frisk

three years of glucagon threads, summarised so you do not have to read them

Paperbranch of 8 comments

three years of glucagon threads, summarised so you do not have to read them, which sounds obvious until you try to state the evidence for it. It is a dual agonist at the GLP-1 and glucagon receptors. The glucagon arm is associated with increased energy expenditure and with effects on hepatic fat, which is why the…

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8 comments, started 1 months ago
u/elin_ferrari47 points·1 months ago

The escalation schedules in the published protocols are slow and deliberate, and the tolerability tables show why. That is a description of the trials rather than a suggestion for anybody.

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u/marisol_friskOP21 points·1 months ago

biopsy-confirmed is not the same as imaging-suggested

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u/border_paperwork11 points·1 months ago

The escalation schedules in the published protocols are slow and deliberate, and the tolerability tables show why.

Adding the standing caveat — unapproved compound, research material is not for human use.

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[deleted]4 points·1 months ago

[deleted]

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u/mod_cold_roommod · c/coldchain16 points·1 months ago

Which phase and which arm are you quoting?

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u/britt_abubakar10 points·1 months ago·edited

Yes — histological endpoints are a far harder bar than the surrogate measures people are used to quoting.

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u/fibre_forward9 points·1 months ago

This. Biopsy-confirmed and imaging-suggested are different evidentiary categories and get run together constantly.

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