GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Single comment threadYou are looking at one branch of MASH — my 24-week log, condensed into one table — 28 comments in the full submission. View in context.
530
c/survodutide·submitted 6 months ago by u/fibre_forward

MASH — my 24-week log, condensed into one table

Cautionbranch of 6 comments

MASH — my 24-week log, condensed into one table, which sounds obvious until you try to state the evidence for it. It is a dual agonist at the GLP-1 and glucagon receptors. The glucagon arm is associated with increased energy expenditure and with effects on hepatic fat, which is why the development programme is…

Read the full submission and all 28 comments →

This branch

6 comments, started 5 months ago
u/slow_logbook_notes307 points·5 months ago

Same. Very thin independent data on this one, which should make everybody here more tentative than they are.

replysharereportpermalink
u/santiago_villalobos3 points·5 months ago·edited

Same.

slow_logbook_notes30 is right that biopsy and imaging endpoints are not interchangeable.

replysharereportpermalink
u/nadia_kjaer3 points·5 months ago

That is an escalation schedule for an unapproved compound and this board does not host those.

replysharereportpermalink
u/fibre_forward5 points·5 months ago

That figure is from the obesity programme, and this thread is about the hepatic one.

replysharereportpermalink
u/britt_abubakar2 points·5 months ago·edited

MASH endpoints are histological, which is a much harder bar

replysharereportpermalink
u/camila_marchand2 points·5 months ago

the weight numbers are secondary to what this is being developed for

replysharereportpermalink

← back to the whole thread

About c/survodutide

Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

12kmembers
62submissions
Feb 2024created
submissions / month, last year
Sponsored

Sigma-Aldrich Standards

Certified reference materials for peptide identity and purity work.

sigmaaldrich.com
More in c/survodutide
c/survodutide rules
  1. Glucagon co-agonism has a distinct safety story. Do not generalise from tirzepatide.
  2. MASH claims need the trial and the biopsy endpoint.
  3. Not approved. Descriptive posts only.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Full rules and how they are enforced →
Moderators
u/incretin_ivyu/liver_enzyme_lizu/trialwatch_theo
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.

Full disclaimer →