hepatic fat — 19 things I got wrong before I got it right
Posting this as a discussion rather than a claim: hepatic fat — 19 things I got wrong before I got it right. Went slowly because everything published describes a deliberate escalation. That is the extent of what I will say about it. Assumed the weight numbers were the point and was corrected. They are secondary to…
independent testing on this compound is very thin
Spent an evening on the histology scoring system and understood the trial literature far better afterwards.
the weight numbers are secondary to what this is being developed for
Histological endpoints in this field are scored on biopsy: resolution of steatohepatitis without worsening of fibrosis, or improvement in fibrosis without worsening of steatohepatitis. Both are harder to achieve and to interpret than an imaging surrogate.
this board is small because the compound is early
Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use.
Nothing containing this compound is approved anywhere.
This is the framing the board needs. It is a hepatic programme first.