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c/survodutide·submitted 2 years ago by u/ismael_nwosu

why does nobody talk about biopsy

Cautionbranch of 6 comments

Slightly embarrassed to be asking this, but: why does nobody talk about biopsy. Bought small because the evidence base is early. That is the only defensible position I could construct. The honest evidence position, written out so this board does not drift. Phase 2 data exists in a specific, biopsy-characterised…

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6 comments, started 2 years ago
u/santiago_villalobos60 points·2 years ago

Is that a weight number from a different programme?

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u/incretin_ivypharmacology16 points·2 years ago

Agreed that the endpoint definitions matter enormously and almost nobody reads them before quoting a response rate.

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u/old_account_20234 points·2 years ago

MASH endpoints are histological, which is a much harder bar

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u/britt_abubakar15 points·2 years ago

this board is small because the compound is early

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u/dario_boateng7 points·2 years ago

This. Biopsy-confirmed and imaging-suggested are different evidentiary categories and get run together constantly.

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u/diego_szabo8 points·2 years ago

Right, and the trial titration was slow for reasons that are visible in the tolerability tables.

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