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c/survodutide·submitted 1 year ago by u/nora_oyelaran

4 months in and hepatic fat is still the thing I get wrong

Paperbranch of 6 comments

4 months in and hepatic fat is still the thing I get wrong, logged the same way every week so the comparison is at least internally fair. The numbers the title promised, since a headline without them is worthless: 4 months. Everything below is context for those. It is a dual agonist at the GLP-1 and glucagon…

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6 comments, started 1 year ago
u/kaia_wojcik40 points·1 year ago

Agreed that the endpoint definitions matter enormously and almost nobody reads them before quoting a response rate.

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u/nora_oyelaran54 points·1 year ago

Independent purity results for this compound are very sparse across the whole site, which means any impression about consistency is built on almost nothing.

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u/clara_restrepo29 points·1 year ago

the titration in the trials was slow and deliberate

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u/nora_oyelaranOP21 points·1 year ago

Biopsy-confirmed population or imaging-selected?

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u/nora_oyelaranOP15 points·1 year ago

Which phase and which arm are you quoting?

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u/incretin_ivyMOD17 points·1 year ago

Removed the escalation schedule. Unapproved compound, no protocols for other members, no exceptions.

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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