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c/sideeffects·posted 2 years ago by u/marit_coelho

17 months in and fatigue is still the thing I get wrong

PSA The Quiet One ×3 Receipts ×2

Check-in as promised in the title: 17 months in and fatigue is still the thing I get wrong.

The relevant figures are 17 months, and they come from the same log I have kept the whole time.

Reflux was the one that got me. Stopped eating in the three hours before bed and it went from nightly to almost never.

Held the dose for an extra six weeks instead of stepping. The muscle cramps settled and I lost the same amount anyway.

Would rather be corrected in public than confident in private.

3,856 up / 1,364 down74% upvoted28 commentsid 1k6inq21 Sep 2023

28 comments

25 in this archive, depth 5

best — the order this archive was captured in

u/thermal_mass_tom253 points·2 years ago

Keeping a log, and what to put in it.

One line a day: dose, day since injection, what the symptom was and how bad out of five, and roughly what you ate. Two months of that fits on one page and the pattern is obvious on paper in a way it never is in your head.

Mine showed a clean day-two-to-day-four window I had been describing as "random". Once you can see the pattern you can plan around it, and planning around it is most of the relief.

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u/gentle_correctionnice about it208 points·2 years ago

How long after a step up did this start?

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u/priya_weiss46 points·2 years ago

How long after a step up did this start?

Disagreeing with this one line: that symptom is not on the wait-and-see list and should not be posted as though it is.

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u/marit_coelhoOP-11 points·2 years ago

Disagreeing with this one line: that symptom is not on the wait-and-see list and should not be posted as though it is.

This is the shape almost everybody here describes, and it is the single most reassuring thing in the thread.

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u/long_post_larry38 points·2 years ago

Kept a one-line-a-day log for two months. The pattern was obvious on paper and invisible in my head.

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u/marit_coelhoOP20 points·2 years ago

What is intake actually looking like — fibre and water especially?

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u/step_therapy_s89 points·2 years ago

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

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u/marit_coelhoOP38 points·2 years ago

How long has it been going on for now?

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u/kavya_kravchenko29 points·2 years ago

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

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u/milan_villalobos14 points·2 years ago·edited

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss.

Agreed, with the caveat that "usually settles" is not "always settles" and the exceptions should still get asked about properly.

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u/aleksi_lehtinen17 points·2 years ago

Severe, or unpleasant? They are genuinely different questions and the answers diverge.

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[deleted]7 points·2 years ago

[deleted]

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u/yannick_barros45 points·2 years ago

How long has it been going on for now?

Adding to this — holding the dose rather than stepping is the option people forget they have.

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u/britt_abubakar37 points·2 years ago

nausea for the first eight days after each step, then nothing, every single time. Predictable enough that I started planning my week around it.

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u/chidi_abubakar24 points·2 years ago

the food noise going quiet is the effect people came for, and early fullness is the toll for the first fortnight

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u/elin_lundgren22 points·2 years ago

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

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u/zaid_balogun15 points·2 years ago

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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u/constipation_clubMOD73 points·2 years ago

Left up. It is a description of one person’s week and it is flagged as such.

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u/chidi_abubakar35 points·2 years ago

Not convinced by that mechanism. Slowed gastric emptying explains fullness and reflux; it does not explain what you are describing.

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u/leila_silva27 points·2 years ago

hair shedding follows the weight loss, not the drug, and it stops

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u/zaid_balogun53 points·2 years ago

Nobody warned me about food noise and I would have liked the warning. It was not dangerous, it was just deeply unpleasant and completely unexpected.

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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