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c/sideeffects·posted 7 months ago by u/liv_vukovic

[Discussion] constipation is doing more work than we give it credit for

Discussion

constipation is doing more work than we give it credit for, which sounds obvious until you try to state the evidence for it.

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

Happy to answer the boring questions. Those are usually the ones worth asking.

268 up / 88 down75% upvoted20 commentsid 1aruk919 Dec 2025

20 comments

15 in this archive, depth 5

best — the order this archive was captured in

u/plain_titration_202415 points·7 months ago

A symptom that begins the day after the shot and fades by day four tracks the exposure curve. One that appears at random in week 96 probably does not, and that is worth saying to a clinician rather than to us.

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[removed]6 points·7 months ago

[removed by moderator]

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u/thermal_mass_tom8 points·7 months ago

Agreed on writing it down. I could not see the pattern until I had six weeks of it on one page.

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u/ferran_krastev2 points·7 months ago

Bought four different things to fix my nausea. What actually worked was eating half as fast.

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u/cesar_oyelaran-7 points·7 months ago

nobody warns you about how much of this is timing rather than dose

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u/baseline_drifteranalytical1 point·7 months ago

How long has it been going on for now?

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u/liv_vukovicOP1 point·7 months ago

Small fix — the shedding follows the rate of weight loss, not the compound, and it is temporary.

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u/nausea_notesside effects1 point·7 months ago

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

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u/ferritin_low1 point·7 months ago

Correction: that is a known effect of reduced intake rather than a direct drug effect. The distinction matters because the fix is different.

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u/sena_teixeira1 point·7 months ago·edited

Nobody warned me about muscle cramps and I would have liked the warning. It was not dangerous, it was just deeply unpleasant and completely unexpected.

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u/aleksi_lehtinen1 point·7 months ago

holding a dose an extra month is a legitimate answer to bad tolerance

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u/adaeze_brandt4 points·7 months ago

Which day of the week relative to the shot does it hit?

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u/thermal_mass_tom1 point·7 months ago

sulphur burps are unpleasant and they are not dangerous

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u/plain_titration_20241 point·7 months ago

Agreed. Slowing down at meals did more for my sulphur burps than everything I bought to fix it, which was embarrassing to discover.

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u/amara_haddad1 point·7 months ago

eating slower does more than most of the supplements people recommend

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Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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