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c/sideeffects·submitted 4 months ago by u/placebo_arm_pam

anyone else notice fatigue kicking in around week 46

Managementbranch of 10 comments

anyone else notice fatigue kicking in around week 46. Full detail below, and I have tried to keep the editorialising out of it. Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working. The effect on gastric emptying is most pronounced…

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10 comments, started 4 months ago
u/long_post_larry165 points·4 months ago

The pattern almost everyone here describes, written out once so it can be linked.

A step up is followed by a rough window — commonly early fullness arriving the day after the shot and easing by day four, worst in the first fortnight, then flattening out. At a stable dose it usually settles further. Constipation and fatigue tend to track intake and fluid rather than the compound directly, which is why the unglamorous answers work.

What sits outside that pattern: severe pain, symptoms that appear from nowhere weeks into a stable dose, or anything getting worse rather than better over a month. None of that is a board question and none of us can answer it for you.

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u/nausea_notesMOD90 points·4 months ago

This one needs a clinician rather than a comment section, and we have said so in the thread rather than removing it.

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u/placebo_arm_pamOP86 points·4 months ago

the first fortnight after a step is the worst of it, then it settles

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u/karma_irrelevant19 points·4 months ago

hair shedding follows the weight loss, not the drug, and it stops

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u/cesar_oyelaran16 points·4 months ago

reflux at night, try not eating in the three hours before bed

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u/placebo_arm_pamOP9 points·4 months ago

How long has it been going on for now?

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u/ahmed_rasmussen69 points·4 months ago

Correction: that is a known effect of reduced intake rather than a direct drug effect. The distinction matters because the fix is different.

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[removed]124 points·4 months ago

[removed by moderator]

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u/blunt_coldbox_2024100 points·4 months ago

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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u/zeynep_zielinski28 points·4 months ago

early fullness on day two and gone by day four is the standard shape

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