[PSA] Wegovy is not what most of this community thinks it is
Wegovy is not what most of this community thinks it is. If you already knew this, the post is not for you and you can scroll on. Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days. The escalation schedule in the trials existed to…
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
The mental model that finally made this click for me: there are two curves, and people watch the wrong one.
The first is exposure, which is set by the dose and smoothed by a week-long half-life. It changes when you change the dose and then settles over about a month. The second is body weight, which is exposure filtered through appetite, food, water, sleep, training and the scale itself, and which moves in steps rather than a line.
Almost every "it stopped working" post is somebody watching curve two over a fortnight and drawing conclusions about curve one. If the appetite effect is still there, exposure is fine. Wait the month.
Do sulphur burps track the day after the shot, or is it there all week?
the appetite signal and the scale move on different clocks
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staying at 0.25mg for an extra month is a legitimate plan
The mental model that finally made this click for me: there are two curves, and people watch the wrong one.
Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.
Minor fix — the half-life is about a week, not about a day. The rest of your point stands.
Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.
This matches me almost exactly, right down to the sulphur burps showing up on the second day and being gone by the fourth.