genuine question about titration that I am slightly embarrassed to ask
Trying to get a straight answer on this: genuine question about titration that I am slightly embarrassed to ask. Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts. Delayed gastric emptying is most pronounced early and…
The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.
That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.
Minor fix — the half-life is about a week, not about a day. The rest of your point stands.
if 0.5mg is working there is no prize for going up
The appetite thing was the surprise. I expected to feel full. What I got was simply not thinking about food between meals.
The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes.
This is the part I would underline for anyone skimming. Everything else in the thread is downstream of it.
Sceptical of the mechanism you are proposing. Gastric emptying slows, it does not stop, and the timings you describe do not follow from it.
Are you measuring anything other than weight? Waist is usually the one that keeps moving.
the food noise going quiet is the effect people actually describe