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c/semaglutide·posted 1 year ago by u/quiet_moderator

anyone else notice weekly dosing kicking in around week 33

Titration Long Haul ×6 Sourced ×1 Well Actually ×1

anyone else notice weekly dosing kicking in around week 33, and the part I actually want to talk about is at the bottom.

reflux made the first fortnight rough at each step up, then flattened out. Predictable enough that I started planning around it.

What I would tell week-one me, in order of how much time it would have saved.

One: the first month is a tolerance check. You are finding out whether you can take this, not how much you will lose. Two: write down the dose, the day and the waist measurement. Three: a stall of under six weeks is weather, not climate. Four: sulphur burps that arrives the day after the shot and fades by day four is the ordinary pattern and it usually settles at a stable dose.

None of that is advice about what you should do. It is the shape of the thing, which nobody explained to me and which the wiki explains better than I just did.

That is everything I have. The rest is opinion and I have tried to keep it out.

8,114 up / 403 down95% upvoted42 commentsid 1c38iq24 Nov 2024

42 comments

20 in this archive, depth 4

best — the order this archive was captured in

u/joaquin_stanescu812 points·1 year ago

STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.

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u/dead_space_doug659 points·1 year ago

Careful. A four-week stall is inside normal variation and treating it as failure is how people escalate for no reason.

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u/quiet_moderatorOPmod378 points·1 year ago

dose day drift of a day either way is fine, the curve barely notices

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u/ravi_bergstrom487 points·1 year ago

Did protein intake change in the same window?

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u/quiet_moderatorOPmod376 points·1 year ago

the food noise going quiet is the effect people actually describe

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u/plain_titration475 points·1 year ago

Same. I sat at 0.25mg for three months because it was working and there was nothing to fix.

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u/lane_map_larrylogistics152 points·1 year ago

What dose and how many weeks at it before this started?

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u/vikram_mbeki39 points·1 year ago

Week 73: 25kg down, reflux basically gone since about week 10, and the honest headline is that nothing dramatic happened. It was boring and it worked.

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u/rasmus_kimani-20 points·1 year ago·edited

protein first, then everything else gets easier

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u/runa_wikstrom286 points·1 year ago

Sat at 1.7mg for four months because it was doing the job. Everyone told me to go up. The one time I did, the only thing that changed was the constipation.

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u/quiet_moderatorOPmod204 points·1 year ago

staying at 1.0mg for an extra month is a legitimate plan

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u/test_it_yourselfvetting87 points·1 year ago

2.4 is a ceiling, not a target

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[deleted]32 points·1 year ago

[deleted]

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u/units_not_mgsyringe math171 points·1 year ago

My stall was eleven weeks. Eleven. Then it moved again without me changing anything at all.

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u/plain_titration105 points·1 year ago

Yes. Week 89 is when almost everybody writes the "is it still working" post, and almost everybody is fine.

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u/anya_salgado73 points·1 year ago

the scale is the least sensitive instrument you own

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u/yara_boateng51 points·1 year ago

Kept a log from week one and the single most useful column turned out to be waist, not weight.

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u/zeynep_zielinski16 points·1 year ago

STEP-1 averaged just under 15% at 68 weeks, so a 10% year is not a failure

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u/customs_seizure_sid215 points·1 year ago

That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.

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u/ffmi_watcher276 points·1 year ago

On the "everybody ends up at 2.4" claim, which comes up every few weeks.

The escalation schedule in the trials was designed to get people to a fixed study dose. Real use is not a trial. The dose that keeps your appetite quiet with side effects you can live with is the dose, and for a lot of people on this board that has been 0.25mg for a very long time.

The counter-argument, which is fair: some people genuinely do need the top of the range, and staying low out of caution costs them months. That is a conversation with someone who knows your history, not with us.

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