[Question] is 98.7% actually fine or am I being sold a rounding error
Posting this because the title is the whole finding — is 98.7% actually fine or am I being sold a rounding error — and a number without its method is a rumour.
98.7% — those are the numbers, and they are the ones I am willing to defend.
The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.
Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.
Sceptical readings welcome. The confident ones are the ones I distrust.
best — the order this archive was captured in
Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.
stalling at 1.7mg is information, not a verdict
My stall was eleven weeks. Eleven. Then it moved again without me changing anything at all.
Correct, and worth adding: the trial average is an average. Half the people in it did worse than 15% and were still on the drug.
sema is weekly for a reason, the half-life does the smoothing
Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the constipation usually fades at a stable dose.
The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does.
Correcting myself from earlier in the thread: I said week 6 and it was week 10. Same shape, wrong number.
Sat at 1.7mg for four months because it was doing the job. Everyone told me to go up. The one time I did, the only thing that changed was the injection-site soreness.
The appetite thing was the surprise. I expected to feel full. What I got was simply not thinking about food between meals.
reflux made the first fortnight rough at each step up, then flattened out. Predictable enough that I started planning around it.
Minor fix — the half-life is about a week, not about a day. The rest of your point stands.
dose day drift of a day either way is fine, the curve barely notices
dose day drift of a day either way is fine, the curve barely notices
Adding one thing to this: the appetite effect and the scale run on separate clocks, so both halves can be true at once.
How long was the stall before you decided it was a stall?
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.