[Meta] the 2.4mg rule is doing its job and people should stop complaining
the 2.4mg rule is doing its job and people should stop complaining, and it will stay as it is unless somebody makes the case to change it.
The numbers the title promised, since a headline without them is worthless: 2.4mg. Everything below is context for those.
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.
Week 94: 29kg down, sulphur burps basically gone since about week 7, and the honest headline is that nothing dramatic happened. It was boring and it worked.
I will update this if the picture changes rather than quietly leaving it up.
best — the order this archive was captured in
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
Dropped my injection day by two days once because of travel. Nothing happened. The panic was worse than the effect.
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg.
sofia_wikstrom is describing the standard shape here and it matches the trial data better than most anecdotes do.
the scale is the least sensitive instrument you own
How long was the stall before you decided it was a stall?
How long was the stall before you decided it was a stall?
Disagree with this specific line. A pause at 1.7mg is not evidence that 1.7mg has stopped working.
My stall was eleven weeks. Eleven. Then it moved again without me changing anything at all.
My stall was eleven weeks.
Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.
Correct, and worth adding: the trial average is an average. Half the people in it did worse than 15% and were still on the drug.
Not convinced. You changed the dose and the week at the same time, so you cannot attribute the change to either.
stalling at 2.4mg is information, not a verdict
week 49 plateau is the most predictable thing in this entire board
Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.
the first four weeks are a tolerance check, not a weight-loss phase
Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.
Standard reminder: no personal titration plans for other members, and no medical advice. Everything else is fine.
injection-site soreness made the first fortnight rough at each step up, then flattened out. Predictable enough that I started planning around it.
Genuine question — is the appetite effect still there, or is it just the scale that has paused?
Disagree. 2.4 is the top of the label, not the goal, and "everyone ends up there" is just survivorship in the posts you read.
Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the sulphur burps usually fades at a stable dose.
The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.
The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does.
Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.
That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.
Cosigning. The appetite change and the scale change ran about three weeks apart for me too.
Do sulphur burps track the day after the shot, or is it there all week?
protein first, then everything else gets easier
staying at 2.4mg for an extra month is a legitimate plan
- 1The weekly interval comes out of the half-life — roughly a week — so you are…8 comments in this branch · started by u/boots_or_bust
- 2STEP-1 ran 68 weeks and landed just under 15% mean body weight change on…6 comments in this branch · started by u/sofia_wikstrom